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Seventeen of the books have been confirmed as having human skin bindings and nine were proven to be not of human origin but of sheep, pig, cow, or other animals.
The phrase 'anthropodermic bibliopegy' has been used at least since Lawrence S. Thompson 's article on the subject, published in One of the earliest examples of a binding claimed to be in human skin is the account published in of the execution of Henry Garnet for his involvement in the Gunpowder Plot , A True and Perfect Relation of the Whole Proceedings Against A copy auctioned in was claimed by the auctioneer to be bound in Garnet's own skin.
An early reference to a book bound in human skin is found in the travels of Zacharias Conrad von Uffenbach.
Writing about his visit to Bremen in Man sollte es wohl vor Schwein-Leder ansehen. There seemed to be nothing remarkable about it, and you couldn't understand why it was here until you read in the front that it was bound in human leather.
This unusual binding, the like of which I had never before seen, seemed especially well adapted to this book, dedicated to more meditation about death.
You would take it for pig skin. During the French Revolution , there were rumours that a tannery for human skin had been established at Meudon outside Paris.
Surviving examples of human skin bindings have often been commissioned, performed, or collected by medical doctors, who have access to cadavers , sometimes those of executed criminals, such as the case of John Horwood in and the Red Barn Murder in The Royal College of Surgeons of Edinburgh preserves a notebook bound in the skin of the murderer William Burke after his execution and subsequent public dissection by Professor Alexander Monro in What Lawrence Thompson called "the most famous of all anthropodermic bindings" is exhibited at the Boston Athenaeum , titled The Highwayman: It is by James Allen , who made his deathbed confession in and asked for a copy bound in his own skin to be presented to a man he once tried to rob and admired for his bravery.
The Newberry Library in Chicago owns an Arabic manuscript written in , with a handwritten note that it is bound in human skin, though "it is the opinion of the conservation staff that the binding material is not human skin, but rather highly burnished goat".
The French astronomer Camille Flammarion 's book Les terres du ciel The Worlds of the Sky was bound with the skin donated from a female admirer.
The National Library of Australia holds a book of 18th century poetry with the inscription "Bound in human skin" on the first page. An exhibition of fine bindings at the Grolier Club in included, in a section of 'Bindings in Curious Materials', three editions of Holbein's ' Dance of Death ' in 19th century human skin bindings;  two of these now belong to the John Hay Library at Brown University.
The identification of human skin bindings has been attempted by examining the pattern of hair follicles , to distinguish human skin from that of other animals typically used for bookbinding, such as calf, sheep, goat, and pig.
This is a necessarily subjective test, made harder by the distortions in the process of treating leather for binding.
Testing a DNA sample is possible in principle, but DNA can be destroyed when skin is tanned, it degrades over time, and it can be contaminated by human readers.
A tiny sample is extracted from the book's covering and the collagen analysed by mass spectrometry to identify the variety of proteins which are characteristic of different species.
PMF can identify skin as belonging to a primate ; since monkeys were almost never used as a source of skin for bindings, this implies human skin.
The Historical Medical Library of the College of Physicians of Philadelphia owns five anthropodermic books, confirmed by peptide mass fingerprinting in ,  of which three were bound from the skin of one woman.
The books can be seen in the associated Mütter Museum. The Wellcome also owns a notebook labelled as bound in the skin of 'the Negro whose Execution caused the War of Independence', presumably Crispus Attucks , but the library doubts that it is actually human skin.
It is now known not to be bound in human skin but horse hide, or a mixture of horse and goatskin. Image for non-commercial use.
Book Bound in Human Skin. Preservation Lab Treatment Report and photographs. Harvard University , Francis A.
Countway Library of Medicine , PA University of Memphis , Ned R. The binding of books in human skin is also a common element within horror films and works of fiction.
From Wikipedia, the free encyclopedia. Thompson, Religatum de Pelle Humana . Possible human skin binding in the Smithsonian Libraries.
Bound in by Josse Schavye  , the same binder of the genuine anthropodermic Vesalius 's Fabrica in Brown University  , and who bound at least four books with human leather .
Panel with Latin inscription in the book: Skin's outermost layer, the stratum corneum, is an effective barrier to most inorganic nanosized particles.
However, in some cases it is desirable to allow particles entry to the body through the skin. Potential medical applications of such particle transfer has prompted developments in nanomedicine and biology to increase skin permeability.
One application of transcutaneous particle delivery could be to locate and treat cancer. Nanomedical researchers seek to target the epidermis and other layers of active cell division where nanoparticles can interact directly with cells that have lost their growth-control mechanisms cancer cells.
Such direct interaction could be used to more accurately diagnose properties of specific tumors or to treat them by delivering drugs with cellular specificity.
The permeability of skin relative to different shapes of nanoparticles has also been studied. Research has shown that spherical particles have a better ability to penetrate the skin compared to oblong ellipsoidal particles because spheres are symmetric in all three spatial dimensions.
Titanium oxide TiO2 , zinc oxide ZnO , and silver nanoparticles are ineffective in penetrating the skin past the stratum corneum.
Because CdSe is toxic to living organisms, the particle must be covered in a surface group. An experiment comparing the permeability of quantum dots coated in polyethylene glycol PEG , PEG- amine , and carboxylic acid concluded the PEG and PEG-amine surface groups allowed for the greatest penetration of particles.
The carboxylic acid coated particles did not penetrate past the stratum corneum. Scientists previously believed that the skin was an effective barrier to inorganic particles.
Damage from mechanical stressors was believed to be the only way to increase its permeability. For example, ultraviolet radiation UVR has been used to slightly damage the surface of skin, causing a time-dependent defect allowing easier penetration of nanoparticles.
When the TEWL reaches its highest value, the maximum density of nanoparticles is able to permeate the skin. Studies confirm that UVR damaged skin significantly increases the permeability.
However, the specific permeability of skin after UVR exposure relative to particles of different sizes and materials has not been determined.
Other skin damaging methods used to increase nanoparticle penetration include tape stripping, skin abrasion , and chemical enhancement.
Tape stripping is the process in which tape is applied to skin then lifted to remove the top layer of skin.
Skin abrasion is done by shaving the top micrometers off the surface of the skin. Chemical enhancement is the process in which chemicals such as polyvinylpyrrolidone PVP , dimethyl sulfoxide DMSO , and oleic acid are applied to the surface of the skin to increase permeability.
Electroporation is the application of short pulses of electric fields on skin and has proven to increase skin permeability.
The pulses are high voltage and on the order of milliseconds when applied. Charged molecules penetrate the skin more frequently than neutral molecules after the skin has been exposed to electric field pulses.
Results have shown molecules on the order of micrometers to easily permeate electroporated skin. A large area of interest in nanomedicine is the transdermal patch because of the possibility of a painless application of therapeutic agents with very few side effects.
Transdermal patches have been limited to administer a small number of drugs, such as nicotine , because of the limitations in permeability of the skin.
Development of techniques that increase skin permeability has led to more drugs that can be applied via transdermal patches and more options for patients.
Increasing the permeability of skin allows nanoparticles to penetrate and target cancer cells. Nanoparticles along with multi-modal imaging techniques have been used as a way to diagnose cancer non-invasively.
Skin with high permeability allowed quantum dots with an antibody attached to the surface for active targeting to successfully penetrate and identify cancerous tumors in mice.
Tumor targeting is beneficial because the particles can be excited using fluorescence microscopy and emit light energy and heat that will destroy cancer cells.
Sunblock and sunscreen are different important skin-care products though both offer full protection from the sun. Titanium dioxide and zinc oxide are two of the important ingredients in sunblock.
In order for sunscreen to be more effective it is necessary to consistently reapply and use one with a higher sun protection factor.
Vitamin A , also known as retinoids , benefits the skin by normalizing keratinization , downregulating sebum production which contributes to acne , and reversing and treating photodamage, striae, and cellulite.
Vitamin D and analogs are used to downregulate the cutaneous immune system and epithelial proliferation while promoting differentiation.
Vitamin C is an antioxidant that regulates collagen synthesis, forms barrier lipids, regenerates vitamin E, and provides photoprotection. Vitamin E is a membrane antioxidant that protects against oxidative damage and also provides protection against harmful UV rays.
Several scientific studies confirmed that changes in baseline nutritional status affects skin condition. The Mayo Clinic lists foods they state help the skin: From Wikipedia, the free encyclopedia.
This article is about skin in humans. For other animals, see skin. Epidermis , dermis , and subcutis , showing a hair follicle , gland , and sebaceous gland.
Intrinsic and extrinsic aging. Retrieved 27 January Pig skin is structurally similar to human epidermal thickness and dermal-epidermal thickness ratios.
Pigs and humans have similar hair follicle and blood vessel patterns in the skin. Biochemically pigs contain dermal collagen and elastic content that is more similar to humans than other laboratory animals.
Finally pigs have similar physical and molecular responses to various growth factors. Pig skin is anatomically, physiologically, biochemically and immunologically similar to human skin CS1 maint: Lookingbill and Marks' Principles of Dermatology.
Your Body Is a Wonderland Human Biology and Health. Skin Digitally printed version ed. The Journal of Physiology. University of California Press.
Progress in Biophysics and Molecular Biology. Journal of Human Evolution. Retrieved 7 January Archived from the original PDF on 31 March The spectrum of laser skin resurfacing: J Am Acad Dermatol.
Journal of Cellular Biochemistry. International Journal of Cosmetic Science. A gateway to onset prevention". Journal of Pharmaceutical Sciences.
Cirne de Castro; M. Skin Pharmacology and Physiology. The dots are in place, she does the joining. I think I've gone off reading 'wood books' and will stick to the less potentially dangerous Kindled editions.
Readers of this will understand my new sensitivities One person found this helpful. At first I didn't think I was going to like this book with the fact it's written in first person narrative but using the voices of 5 very different characters.
They each have their own chapters and their own style of talking. For some time I couldn't work out how Sor Loreta was going to fit into the story but when she does finally join the main story it is vicious and compelling.
How wrong I was!! This book is brilliant. I couldn't put it down. It's just so compulsive to keep going to find out what will happen next and how it will all work out.
It is fabulously written and each character is fit to burst with personality and depth. I also enjoy the extra bit at the end of the book about the research completed in order to try and keep historical accuracy, which led to the authors ideas for the characters.
The best thing about reading this on Kindle was I didn't realise how big the book was. I was reading and reading and didn't seem to be making a dent.
If I had seen how big the book was in a shop it might have unnerved me a little and possibly put me off. As it is, I'm very glad I read this.
I read this at the suggestion of a friend, so expected good things before I even dipped into the first page. Was unsure whether I would enjoy the format of each chapter being written in the style of different characters' diary entries but it flowed surprisingly well and really gave a depth to the personalities that would have been difficult to achieve otherwise.
Great plot, layer upon layer of deep metaphorical references, thoroughly enjoyable. I was slightly shocked at how little I was shocked by the actual "books of human skin" but that perhaps says more about me than the detail afforded to this part of the tale.
I think my mind skips over anything too distressing, but it is certainly not as graphic as I had feared. I would have no hesitation in recommending this book, particularly for groups who may wish to delve a little deeper into the psyche of the characters.
While not as gruesome as the title would have you believe, The Book of Human Skin is definitely a good read. It starts off a little slow, and the constant changing of narrator one per chapter, with each chapter being very short meant that it took a little while to develop into a cohesive narrative.
But when it got going it really did get going! Minguillo is a detestable creature, Marcella is a little too good to be true, Gianni is utterly loveable, Santo is determined and strong, and Sor Loreta is deranged.
Theirs is the tale of the Fasan family, a brother's hatred of his younger sister who stands to inherit the family fortune in place of him, and his machinations to have her disinherited in favour of himself.
Minguillo is truly loathsome character, but Marcella's strength of spirit triumphs with the help of the many who love her, and allows for a satisfying ending.
I find it really irritating. This books starts off with Gianni's diary, written exactly in this way. I thought I was going to hate this book! Actually it works really well.
The book is split into chapters with each of the main characters telling their part and version of the story.
It was a tad confusing at the start as the timelines don't gel too well, but you soon get into the swing of it. It moves across from Venice to South America and most of the characters take the journey.
The way the book is written and structured fills in the gaps for each character's diary. There are some truly evil and insane characters in this book and their descent into madness is quite graphic in places.